Endocrine Abstracts

Introduction: Addison’s disease (AD) is a rare condition (reported prevalence of 40–110 per million) that requires prompt recognition and optimal management to prevent the risks associated with cortisol deficiency.Aim: To assess the prevalence, presentation and clinical course of patients diagnosed with AD in the geographical area of Banbury in Oxfordshire.Patients and methods: Notes of subjects with AD currently register...

Introduction: Cushing’s disease (CD) is a rare condition, associated with significant morbidities and potentially fatal, if untreated.Objective: To assess the long-term morbidities in a large series of patients with CD during a prolonged follow-up period.Patients and methods: All subjects with CD who presented/followed-up in our Department between 01/1967 and 06/2009 were studied. All information was collected as documented in...

Background and Aim: Over the past years, hybrid closed-loop (HCL) systems have emerged as the state-of-the art treatment of type 1 diabetes (T1D), and there is sufficient evidence to support their safety and value. The aim of this review was to evaluate all the available literature regarding the impact of HCL systems on diabetes management compared to sensor augmented pump (SAP) systems.Methods: An extensive literature search was conducted through electr...

Introduction: Menopause marks a period of significant changes on hormones and on the women’s lifestyle, which can interfere with their subsequent health. Menopause marks not only the end of the woman’s reproductive life, but also the upcoming associated risks for many morbidities, as well. The increasing prevalence of diabetes (either type 1 Diabetes Mellitus (T1DM) or type 2 Diabetes Mellitus (T2DM) renders a necessity to investigate its effects on women’s a...

Cushing’s disease (CD) is a rare condition, associated with significant morbidities.The long-term morbidities in a series of patients with CD who presented in two tertiary referral centres between 01/1967-06/2009 were assessed. All information was collected as documented in the records of the patients.224 patients were identified (174 females) with median age at diagnosis 39 years (range 10–76 (females 38 (12–72) &#1...

IntroductionThe prevalence of Non-Alcoholic Fatty Liver Disease (NAFLD) varies according to age, gender and nationality. In the general population, the incidence is about 15–25%. Liver disease increases with age and its prevalence is higher in menopausal women suggesting that steroid sex hormone metabolism may play a role in the pathogenesis of NAFLD.AimThe purpose of this systematic review was to invest...

Introduction: Type 2 diabetes mellitus (DM2) is the most common disease in the spectrum of metabolic disorders, with its prevalence increasing significantly in recent years. It is estimated that by 2035, 592 million people will have type 2 diabetes. People with type DM2 have high rates of depression and a quality of life that is poorer than that of the general population. Another important factor in the quality of life of people with DM2 is the compliance of patients with the ...

Introduction: Diabetes mellitus (DM) is a disease that shows a rapid increase over the recent years and is a major cause of morbidity and mortality. Thus new ways of prevention and treatment are needed and constantly being developed. As a lifelong challenge, DM is likely to affect one’s life in a variety of ways. It requires daily planning and decision making. Self-care is a vital component of the disease. Knowledge consists of information about the disease and its manage...

Patients with adrenal insufficiency require increased hydrocortisone (HC) replacement doses during surgery, trauma and infection to avoid life-threatening adrenal crisis. However, currently administered HC doses are chosen empirically rather than on rational grounds, with huge variability in administration modes, total dose and dosing intervals. To conclusively determine serum cortisol levels observed under stress conditions, we firstly collected blood samples from healthy con...

Patients with adrenal insufficiency (AI) require adjustment of hydrocortisone (HC) dose to avoid life-threatening adrenal crisis during illness, surgery and trauma. However, current dose recommendations are based on empirical grounds only and choice of dose and administration modes vary considerably. We designed the PACS study to compare cortisol levels achieved by currently recommended HC stress doses to those in i) healthy controls (n=85, 21–70 years), ii) mili...